Los Angeles. 1983. A storm is coming and its name is crack. Set against the infancy of the crack cocaine epidemic and its ultimate radical impact on the culture as we know it, the story follows numerous characters on a violent collision course.
In early-1970s Las Vegas, Sam "Ace" Rothstein gets tapped by his bosses to head the Tangiers Casino. At first, he's a great success in the job, but over the years, problems with his loose-cannon enforcer Nicky Santoro, his ex-hustler wife Ginger, her con-artist ex Lester Diamond and a handful of corrupt politicians put Sam in ever-increasing danger.
An exploration of the United States of America's war on drugs from multiple perspectives. For the new head of the Office of National Drug Control Policy, the war becomes personal when he discovers his well-educated daughter is abusing cocaine within their comfortable suburban home. In Mexico, a flawed, but noble policeman agrees to testify against a powerful general in league with a cartel, and in San Diego, a drug kingpin's sheltered trophy wife must learn her husband's ruthless business after he is arrested, endangering her luxurious lifestyle.
Two children, Ignacio and Enrique, know love, the movies and fear in a religious school at the beginning of the 1960s. Father Manolo, director of the school and its professor of literature, is witness to and part of these discoveries. The three are followed through the next few decades, their reunion marking life and death.
After leaving jail, Víctor is still in love with Elena. But, she's married to the former cop-now basketball player-who became paralyzed by a shot from Víctor's gun.
In Oklahoma, Agnes, a lonely waitress living in an isolated and dilapidated roadside motel, meets Peter, a quiet and mysterious man with whom she establishes a peculiar relationship.
On New Year's Eve, inside a police station that's about to be closed for good, officer Jake Roenick must cobble together a force made up cops and criminals to save themselves from a mob looking to kill mobster Marion Bishop.
When Kanako, a model daughter and a brilliant student, disappears, her mother asks her ex-husband, a violent former policeman, to find her. As his investigation progresses, his idealized image of Kanako cracks: the girl hides a dark life that her father can not even imagine.
Two homicide detectives are on a desperate hunt for a serial killer whose crimes are based on the "seven deadly sins" in this dark and haunting film that takes viewers from the tortured remains of one victim to the next. The seasoned Det. Sommerset researches each sin in an effort to get inside the killer's mind, while his novice partner, Mills, scoffs at his efforts to unravel the case.