In 1458, five years after the fall of Constantinople to the Turk, eighteen cardinals meet to elect a new pope. Rodrigo Borgia, a 27 year old cardinal learns to play a very dangerous game.
In autumn of 1526, the Emperor, Charles V, sends his German landsknechts led by Georg von Frundsberg to march towards Rome. The inferior papal armies, commanded by Giovanni de'Medici, try to chase them in the midst of a harsh winter. Nevertheless, the Imperial armies manage to cross the rivers along their march and get cannons thanks to the maneuvers of its Lords. In a skirmish, Giovanni de'Medici is wounded in the leg by a falconet shot. The attempts to cure him fail and he dies. The Imperial armies assault Rome. The film is beautifully but unassumingly set, and shows the hard conditions in which war is waged and its lack of glory. It ends straightforwardly with the declaration made after the death of Giovanni de'Medici by the commanders of the armies in Europe of not using again fire weapons because of their cruelty.
Frustrated with the direction of the church, Cardinal Bergoglio requests permission to retire in 2012 from Pope Benedict. Instead, facing scandal and self-doubt, the introspective Pope Benedict summons his harshest critic and future successor to Rome to reveal a secret that would shake the foundations of the Catholic Church.