Told in flashback from the perspective of Megan, the storyline unfolds when her commitment to faith and family is renewed after reading the blog of Julie Locke, the online journal that Julie kept after her 13 months old Dax was diagnosed with Acute Myeloid Leukemia (AML).
Erik, a loner, finds a friend in Dexter, an eleven-year-old boy with AIDS. They vow to find a cure for AIDS together and save Dexter's life in an eventful summer.
A young boy, Alfred, is dying, but through the stories about Helium, a magical fantasy world, told by the hospital's eccentric janitor, Enzo, Alfred regains the joy and happiness of his life, and finds a safe haven away from daily life.