Martin Lomax is a mentally challenged man who works as a security guard in an underground parking garage. He lives with an oppressive mother and is obsessed with the horror film "The Human Centipede (First Sequence)", so much so that he keeps a real centipede at home. Martin feels the need to act on his obsession, so he decides to kidnap victims from the parking lot every night and take them to a dirty and cramped place, with one goal in mind: to create a real human centipede, made up of twelve people.