Tori, a beautiful young woman, accidentally ends up with a criminal's merchandise and is accused of the death of a member of a Colombian cartel: “El Jefe.” Desperate Tori asks for help from her friends Camila and Priz. The three decide to sell the product to a well-known local cartel to solve their problems and request the help of "Shakira", a hitwoman who knows the market, but they do not know that the buyer with whom they are doing business is the original owner of the merchandise.
Former Colonel Fernandez is appointed Minister of the National Anti-Drug Agency (SENAD) and purges the special forces to fight the first of many battles against drug trafficking on the border of Paraguay and Argentina.