In early-1970s Las Vegas, Sam "Ace" Rothstein gets tapped by his bosses to head the Tangiers Casino. At first, he's a great success in the job, but over the years, problems with his loose-cannon enforcer Nicky Santoro, his ex-hustler wife Ginger, her con-artist ex Lester Diamond and a handful of corrupt politicians put Sam in ever-increasing danger.
Molly Bloom, a young skier and former Olympic hopeful becomes a successful entrepreneur (and a target of an FBI investigation) when she establishes a high-stakes, international poker game.
Maverick is a gambler who would rather con someone than fight them, and needs an additional three thousand dollars in order to enter a winner-takes-all poker game that begins in a few days, so he joins forces with a woman gambler with a marvellous southern accent, and the two try and enter the game.
Gerry is a talented but down-on-his-luck gambler whose fortunes begin to change when he meets Curtis, a younger, highly charismatic poker player. The two strike up an immediate friendship and Gerry quickly persuades his new friend to accompany him on a road trip to a legendary high stakes poker game in New Orleans. As they make their way down the Mississippi River, Gerry and Curtis manage to find themselves in just about every bar, racetrack, casino, and pool hall they can find, experiencing both incredible highs and dispiriting lows, but ultimately forging a deep and genuine bond that will stay with them long after their adventure is over.
A professional poker player whose astounding luck at the table fails to translate into his lonesome love life attempts to win the World Series of Poker while simultaneously earning the affections of a beautiful Las Vegas singer.
After moving to a retirement community, loner Martha eventually befriends her fun-loving neighbor, Sheryl, and forms a cheerleading club for young-at-heart seniors, though they face roadblocks along the way.
Elizabeth has just been through a particularly nasty breakup, and now she's ready to leave her friends and memories behind as she chases her dreams across the country. In order to support herself on her journey, Elizabeth picks up a series of waitress jobs along the way. As Elizabeth crosses paths with a series of lost souls whose yearnings are even greater than her own, their emotional turmoil ultimately helps her gain a greater understanding of her own problems...
As an ex-gambler teaches a hot-shot college kid some things about playing cards, he finds himself pulled into the world series of poker, where his protégé is his toughest competition.