Based on the true life experiences of poet Jimmy Santiago Baca, the film focuses on half-brothers Paco and Cruz, and their bi-racial cousin Miklo. It opens in 1972, as the three are members of an East L.A. gang known as the "Vatos Locos", and the story focuses on how a violent crime and the influence of narcotics alter their lives. Miklo is incarcerated and sent to San Quentin, where he makes a "home" for himself. Cruz becomes an exceptional artist, but a heroin addiction overcomes him with tragic results. Paco becomes a cop and an enemy to his "carnal", Miklo.
Two gangsters seek revenge on the state jail worker who during their stay at a youth prison sexually abused them. A sensational court hearing takes place to charge him for the crimes.
During his 18 years in Folsom Prison, street-gang leader Santana rules over all the drug-and-murder activities behind bars. Upon his release, Santana goes back to his old neighborhood, intending to lead a peaceful, crime-free life. But his old gang buddies force him back into his old habits.
Tano is 16-years-old and is already sitting in jail. In 48 hours he’s a free man and off to the wedding of his brother. In the two days he recounts his neighborhood in a section of Sevilla.