The film is set in 1521 Antwerp, in a Europe ravaged by religious wars, and during the early years of the Reformation. It tells the story of the twelve year old, Falko Voeten – a printer’s son. When Falko’s father, Klaas Voeten, a printer of forbidden literature, is caught by the Inquisition for printing a letter written by Maarten Luther; Falko is unwittingly propelled into helping his father and into searching for the letter. Threatened by the Inquisition but aided by Marieke, a Catholic orphan girl from the underground sewers, Falko is faced with a race against time if he is to save his father from being executed for heresy.
A few decades after the destruction of the Inca Empire, a Spanish expedition led by the infamous Aguirre leaves the mountains of Peru and goes down the Amazon River in search of the lost city of El Dorado. When great difficulties arise, Aguirre’s men start to wonder whether their quest will lead them to prosperity or certain death.