An ominous dream convinces 77-year-old Dayanand Kumar that his end could be near. He takes the news to his son Rajiv, knowing he wants to breathe his last in the holy city of Varanasi and end the cycle of rebirth, by attaining salvation. Being the dutiful son he is, Rajiv is left with no choice but to drop everything and make the journey with his stubborn father. Daya and Rajiv check into Mukti Bhawan (Hotel Salvation) in Varanasi, a guesthouse devoted to people who want to die there. But as the days go by, Rajiv struggles to juggle his responsibilities back home, while Daya starts to bloom in the hotel. Rajiv gives his father a shot at salvation but as family bonds are tested, he finds himself torn, and not knowing what he must do to keep his life together.
Filmmaker Nicky offers to track down the son that Mamie gave up for adoption nearly two decades before. Meanwhile, Mamie's stepbrother (and the father of her child), Charley, along with his boyfriend, Gil, try to find out what became of the sperm Gil donated to a lesbian couple. Finally, singer Jude becomes entangled in a love triangle with androgynous drummer Otis and his conservative father.
Charlie gets released from an insane asylum and moves in with Miranda, the young daughter he left behind. Charlie believes that there is treasure hidden beneath the local Costco, so he puts together a plan to unearth the loot. By convincing Miranda to quit her job at McDonald's and instead work at the wholesale store, he is able to obtain a key. Although Miranda is skeptical, she helps her father with his irrational quest.
In an attempt to sign a Hollywood starlet, struggling talent agent and former child star Howard Holloway must contend with her volatile father, a scheming long-time rival, and a producer and casting director who despise him.
Lizzie's best friend, Andie, becomes pregnant and offers to give the baby to her. Lizzie's husband, Peter, reluctantly goes along with being the child's father, and Andie moves into the guest room for the remainder of the pregnancy.
Beautiful aspiring rock star Jude is stuck in a rut - relegated to recording commercial jingles and lost in a series of one night stands. When she is evicted from her Brooklyn apartment, she is forced to move into the Hamptons home of her wealthy - and selfish - father Paul Lombard, an over-the-hill, Sinatra-esque crooner angling for a musical comeback.
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