It is 1879 in the Dakota Territories, a band of men who set out to find and recover a family of settlers that has mysteriously vanished from their home. Expecting the offenders to be a band of fierce natives, but they soon discover that the real enemy stalks them from below.
During a shootout in a saloon, Sheriff Hunt injures a suspicious stranger. The doctor's assistant, wife of the local foreman, tends to him in prison. That night, the town is attacked and they both disappear—only the arrow of a cannibal tribe is found. Hunt and a few of his men go in search of the prisoner and the foreman's wife.
Elmer Winslow is a soldier on the run from the Union Army, and Luke Budd is a cowboy with a broken heart. When the two misfits rob the corrupt sheriff of an old west town, they have no idea that a plague of zombies is sweeping the country, or that Geronimo's sexy niece may be their only hope of survival.